The Essential Role of Protein in Mental Health
While protein is widely recognized as a fundamental element for physical vitality, particularly associated with muscle growth and repair, its profound impact on mental health is often overlooked.
Exploring the neurological influences of protein, which encompass its pivotal role in neurotransmitter production, blood sugar stabilization, and the enhancement of neuronal connectivity, reveals the intricate and multifaceted nature of this essential macronutrient.
Influencing Neurotransmitters: Serotonin and Dopamine
Protein has the potential to play a role in common mental disorders like anxiety and depression by influencing neurotransmitters (NTs), which are like little messengers in your brain. NTs are active chemicals that help signals move between nerve cells.
Certain amino acids, especially tryptophan and tyrosine, found in high-quality protein sources, act as crucial building blocks for NTs like serotonin and dopamine.
Serotonin is closely tied to the stress response and affects behaviours like mood and appetite. Tryptophan, the main precursor for serotonin, competes with six other amino acids when entering the blood-brain barrier.
Choosing high-quality protein sources with an abundance of amino acids increases the chance of tryptophan successfully crossing into the brain, ultimately boosting brain serotonin levels. On the flip side, tyrosine, the precursor to dopamine, plays a role in the brain’s ‘reward centre’ influencing attention and motivation.
Prioritizing high-quality protein sources rich in amino acids could be a potential strategy to help maintain neurotransmitter balance and prevent brain and psychiatric disorders.
Blood Sugar Regulation
In addition to influencing neurotransmitters, meals rich in protein play a role in stabilizing blood sugar levels by limiting the absorption of glucose in specific cells, such as caco-2 cells.
There is growing evidence suggesting that plant-based proteins, in particular, may improve glucose regulation by curbing the uptake of glucose in the intestines. This regulatory function goes beyond maintaining metabolic balance; it extends to mental wellbeing since fluctuations in blood sugar have been linked to mood swings and cognitive disturbances.
Fluctuations in blood sugar, marked by sudden spikes and drops, prompt the release of autonomic regulatory hormones – cortisol, adrenaline and growth hormone. These counter-regulatory hormones likely play a role in feelings of anxiety and irritability.
For those with a busy lifestyle, convenient plant-based protein options, like Form protein blends, become crucial for maintaining balanced sugar levels and mood on the go. It’s essential to choose clean sources of protein like Form Nutrition, which have undergone third party testing.
This step is important because certain additives in the food industry, which may not be as clean, have been associated with diabetes and increased insulin resistance. Third-party testing is a process that ensures products align with specific quality standards and specifications, covering factors like purity, safety and efficacy.
Brain Structure and Function
Moreover, the structural and functional integrity of the brain relies heavily on many proteins. This macronutrient supports the formation of neural connections and synaptic integrity. These proteins have limited lifetimes and need to be constantly replaced with newly made copies to keep everything running smoothly.
Research from the National Institutes of Health revealed that when someone experiences a common mental disorder like depression, their brain may lose grey matter volume (GMV). Studies have shown that GMV is higher in people who consume foods rich in biologically active proteins.
The overall health of brain cells is crucial for emotional regulation and memory retention.
Final Thoughts
Making the choice to incorporate high-quality protein sources goes beyond mere dietary decisions; it becomes a holistic investment in both physical and mental health.
The manifold benefits of protein extend beyond its conventional association with muscle development and physical strength, playing a pivotal role in nurturing brain health and overall mental vitality.
References:
Almarshad, M.I, Algonaiman, R., Alharbi, H.F., Almujaydil, M.S, Barakat, H. (2022). Relationship between Ultra-Processed Food Consumption and Risk of Diabetes Mellitus: A Mini-Review. Nutrients. 7;14(12):2366. doi: 10.3390/nu14122366
Kokubun, K., Yamakawa, Y. (2019). Association Between Food Patterns and Gray Matter Volume. Frontier Human Neuroscience. 29;13:384. doi: 10.3389/fnhum.2019.00384
Cohen LD, Ziv T, Ziv NE. (2022). Synapse integrity and function: Dependence on protein synthesis and identification of potential failure points. Frontier Molecular Neuroscience. 13;15:1038614 doi: 10.3389/fnmol.2022.1038614
Firth, J., Gangwisch, J.E., Borsini, A., Wootton, R.E., Mayer, E.A. (2020). Food and mood: how do diet and nutrition affect mental wellbeing? BMJ; 369: doi: 10.1136/bmj.m2382
Dugardin, C., Fleury, L., Touche, V., Ahdach, F., Lesage, J., Tenenbaum, M., Everaert, N., Briand, O., Lestavel, S., Ravallec, R., Cudennec, B. (2022). An Exploratory Study of the Role of Dietary Proteins in the Regulation of Intestinal Glucose Absorption. Frontiers in Nutrition
Gasmi, A., Nasreen, A., Menzel, A., Gasmi Benahmed, A., Pivina, L., Noor, S., Peana, M., Chirumbolo, S., Bjørklund, G. (2022) Neurotransmitters Regulation and Food Intake: The Role of Dietary Sources in Neurotransmission. Molecules. 26;28(1):210. doi: 10.3390/molecules28010210.
Kanova, M., Kohout, P. (2021). Serotonin—Its Synthesis and Roles in the Healthy and the Critically Ill. International Journal of Molecular Sciences. 22(9):4837.
Sheikhi, A., Siassi, F., Djazayery, A. (2023). Plant and animal protein intake and its association with depression, anxiety, and stress among Iranian women. BMC Public Health 23, 161 doi.org/10.1186/s12889-023-15100-4